Description

Monohydroxy Netupitant is a key pharmaceutical intermediate in the synthesis of Netupitant, a potent neurokinin-1 (NK1) receptor antagonist. This compound is critical for ensuring the purity, efficacy, and regulatory compliance of the final active pharmaceutical ingredient (API). It is primarily required by manufacturers in the pharmaceutical and fine chemical industries engaged in the production of antiemetic medications.

Application

• Primary Intermediate for the synthesis of Netupitant, an antiemetic drug used in combination with Palonosetron.
• Research & Development of novel NK1 receptor antagonists and related therapeutic agents.
• Process Chemistry for scale-up and optimization of pharmaceutical manufacturing routes.
• Quality Control and analytical reference standard for API batch testing and validation.
• Contract Manufacturing for companies outsourcing critical synthesis steps.
• Regulatory Filings as a documented starting material in Drug Master Files (DMFs).

Basic Information

Product Name	Monohydroxy Netupitant
CAS No.	910808-12-7
Molecular Formula	C22H23F6N3O2
Molecular Weight	475.43 g/mol
Synonyms	2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methyl-1H-imidazol-1-yl)-2-(hydroxymethyl)phenyl]propanamide; Netupitant Hydroxy Intermediate; Netupitant Impurity; Netupitant Related Compound; (2R)-2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylimidazol-1-yl)-2-(hydroxymethyl)phenyl]propanamide; AKOS BRN 0747; Monohydroxy Netupitant Impurity
EINECS	Contact for details

Quality Control

Our Monohydroxy Netupitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.