Description

Suberic Acid Bis(3-Sulfo-n-Hydroxysuccinimide Ester)-D4 Disodium Salt is a deuterated, water-soluble, homobifunctional crosslinking reagent designed for advanced bioconjugation. This compound matters for researchers and manufacturers requiring high-precision labeling and stable isotope tracing in complex biological systems. It is primarily needed by the pharmaceutical, proteomics, and diagnostic industries for applications such as protein-protein crosslinking, antibody-drug conjugate (ADC) development, and mass spectrometry-based biomarker discovery.

Application

• Bioconjugation and Crosslinking: A key reagent for covalently linking biomolecules, such as proteins, peptides, and antibodies, due to its amine-reactive NHS ester groups.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis and research of ADCs, enabling the stable attachment of cytotoxic payloads to monoclonal antibodies.
• Proteomics and Mass Spectrometry: The deuterium (D4) labeling provides an internal standard for quantitative proteomic analysis, improving accuracy in protein quantification and interaction studies.
• Diagnostic Assay Development: Facilitates the creation of stable, labeled detection complexes in immunoassays and biosensors.
• Biomaterial and Surface Modification: Employed to functionalize surfaces (e.g., chips, nanoparticles) with biomolecules for research in tissue engineering and drug delivery systems.
• Stable Isotope Labeling: Serves as a critical tool in metabolic pathway tracing and pharmacokinetic studies within drug discovery.

Basic Information

Product Name	Suberic Acid Bis(3-Sulfo-n-Hydroxysuccinimide Ester)-D4 Disodium Salt
CAS No.	910292-87-4
Molecular Formula	C20H18D4N2Na2O16S2
Molecular Weight	Contact for details
Synonyms	BS3-d4 (Disodium Salt); Deuterated BS3; Bis(sulfosuccinimidyl) suberate-d4 disodium salt; Suberic acid bis(N-hydroxysulfosuccinimide ester)-d4 disodium salt; 3,3'-Dithiobis(sulfosuccinimidyl propionate)-d4; DSS-d4 (Disodium Sulfonate); Homobifunctional NHS Ester Crosslinker-d4; Water-soluble Crosslinking Reagent-d4
EINECS	Contact for details

Quality Control

Our Suberic Acid Bis(3-Sulfo-n-Hydroxysuccinimide Ester)-D4 Disodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and critical performance parameters. We adhere to relevant industry standards for fine chemicals and bio-conjugation reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Solubility	Freely soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.