Description

Boc-Thr(Fmoc-Ala)-OH is a protected dipeptide building block of significant importance in solid-phase peptide synthesis (SPPS). Its value lies in the orthogonal protection scheme, where the Boc (tert-butoxycarbonyl) group protects the N-terminus and the Fmoc (9-fluorenylmethoxycarbonyl) group protects the side chain of threonine, allowing for selective deprotection and controlled chain elongation. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical intermediate for the controlled, sequential assembly of complex peptide sequences using Boc-chemistry strategies.
• Pharmaceutical Research & Development: Used in the discovery and development of new peptide drugs, including hormones, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation: Serves as a building block for creating peptide-protein or peptide-small molecule conjugates for drug delivery and diagnostic applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: A key reagent for studying peptide structure, function, and synthesis methodologies in university and government laboratories.
• Production of Custom Peptides: Used by CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of peptides for clients.

Basic Information

Product Name	Boc-Thr(Fmoc-Ala)-OH
CAS No.	909115-21-5
Molecular Formula	C27H32N2O8
Molecular Weight	512.56 g/mol
Synonyms	Boc-Thr(Fmoc-Ala)-OH; Boc-L-Threonine(Fmoc-L-alanine)-OH; (2S,3R)-3-[(tert-Butoxycarbonyl)amino]-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]butanoic acid; tert-Butyl N-[(2S,3R)-1-[(9H-fluoren-9-ylmethoxy)carbonylamino]-3-hydroxy-1-oxobutan-2-yl]carbamate; Boc-Thr(Fmoc-Ala); Fmoc-Ala-Thr(Boc)-OH; Protected Thr-Ala dipeptide; Boc-Threonine(Fmoc-Alanine)
EINECS	Contact for details

Quality Control

Our Boc-Thr(Fmoc-Ala)-OH is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.