Description

n-Succinimidyl-1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetate is a high-purity, activated ester derivative used as a critical intermediate in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring reliable, high-quality building blocks for complex molecule construction. It is primarily utilized in pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel indole-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation Reagent: Used for the covalent attachment of pharmacophores or labels to biomolecules like proteins or peptides via its reactive succinimidyl ester group.
• Chemical Biology Research: Employed in the development of molecular probes and tools for studying biological pathways and target engagement.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis: A valuable starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.

Basic Information

Product Name	n-Succinimidyl-1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetate
CAS No.	104425-42-5
Molecular Formula	C23H19ClN2O6
Molecular Weight	454.86 g/mol
Synonyms	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid N-hydroxysuccinimide ester; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2,5-dioxo-1-pyrrolidinyl ester; 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetoxysuccinimide; NSC 339586; Succinimidyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate; N-Succinimidyl 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate
EINECS	Contact for details

Quality Control

Our n-Succinimidyl-1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indole-3-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when possible and allowed to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.