Description

N,N''-Carbonyl-Bis(L-Valine) Diisopropyl Ester is a protected dipeptide derivative, specifically a valine-based building block. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering controlled reactivity and stereochemical purity. It is primarily utilized by research institutions and pharmaceutical manufacturers involved in the development of active pharmaceutical ingredients (APIs), peptide-based therapeutics, and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of therapeutic peptides.
• API Development: Used in the research and production of active pharmaceutical ingredients, particularly those with valine-rich sequences.
• Peptidomimetics Synthesis: Serves as a precursor for creating non-natural peptide analogs with enhanced stability and bioavailability.
• Bioconjugation: Can be employed in the preparation of peptide-protein conjugates for diagnostic and therapeutic applications.
• Chemical Biology Research: Utilized as a tool compound in studying enzyme-substrate interactions and protein folding.
• Custom Peptide Services: A fundamental reagent for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide synthesis.

Basic Information

Product Name	N,N''-Carbonyl-Bis(L-Valine) Diisopropyl Ester
CAS No.	18434-91-8
Molecular Formula	C19H34N2O5
Molecular Weight	370.49 g/mol
Synonyms	Bis(L-valine) N-carboxy anhydride diisopropyl ester; N-Carboxy-bis(L-valine) diisopropyl ester; Diisopropyl N,N'-carbonylbis(L-valinate); L-Valine, N,N'-carbonylbis-, diisopropyl ester; (S,S)-Diisopropyl 2,2'-(carbonylbis(azanediyl))bis(3-methylbutanoate); Valine-NCA diisopropyl ester; Protected L-Valine dimer
EINECS	Contact for details

Quality Control

Our N,N''-Carbonyl-Bis(L-Valine) Diisopropyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L,L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.