Description

Dmt-2'o-Tbdms-Ra(Bz) Phosphoramidite is a highly specialized, protected phosphoramidite monomer used in the automated solid-phase synthesis of oligonucleotides. This compound is critical for the precise and efficient incorporation of modified nucleosides into DNA and RNA sequences, enabling advanced research and therapeutic development. It is an essential raw material for biotechnology, pharmaceutical R&D, and diagnostic companies focused on antisense oligonucleotides, siRNA, and other nucleic acid-based technologies. The product is supplied under stringent quality control to ensure optimal coupling efficiency and sequence fidelity.

Application

• Oligonucleotide Synthesis: Key building block for the automated solid-phase synthesis of DNA and RNA strands.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense drugs, siRNA, and aptamers for targeted therapies.
• Research & Diagnostic Probes: Synthesis of labeled or modified probes for genomics, PCR, and hybridization assays.
• Synthesis of Modified Nucleosides: Introduction of specific protected ribose modifications into oligonucleotide chains.
• High-Throughput Synthesis Platforms: Compatible with commercial DNA/RNA synthesizers for scale-up and library production.
• Development of Nucleic Acid Libraries: Used in the creation of diverse oligonucleotide pools for SELEX and other screening technologies.

Basic Information

Product Name	Dmt-2'o-Tbdms-Ra(Bz) Phosphoramidite
CAS No.	104992-55-4
Molecular Formula	C46H63N4O8PSi
Molecular Weight	859.07 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N6-benzoyladenosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5'-DMT-2'-O-TBDMS-N6-Bz-Adenosine 3'-CE Phosphoramidite; 2'-O-TBDMS-A(Bz) Phosphoramidite; N6-Benzoyl-2'-O-(tert-butyldimethylsilyl)adenosine 5'-O-(4,4'-dimethoxytrityl) 3'-O-(2-cyanoethyl diisopropylphosphoramidite); Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[(1,1-dimethylethyl)dimethylsilyl]-N6-benzoyl-, 3'-[2-cyanoethyl (diisopropylamino)phosphoramidite]
EINECS	Contact for details

Quality Control

Every batch of Dmt-2'o-Tbdms-Ra(Bz) Phosphoramidite is manufactured and tested to meet the exacting standards required for oligonucleotide synthesis. Our rigorous quality control includes comprehensive analytical testing (HPLC, NMR, MS) to ensure high purity, correct structure, and optimal performance in automated synthesizers. A Certificate of Analysis (COA) detailing purity, identity, and moisture content is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. Due to its hygroscopic and moisture-sensitive nature, the product should be handled in a controlled, dry atmosphere and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.