Description

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride is a highly versatile and widely used water-soluble carbodiimide coupling agent. It is essential for facilitating the formation of amide bonds between carboxylic acids and amines, a fundamental reaction in organic synthesis and bioconjugation. This reagent is critical for researchers and manufacturers in the pharmaceutical, biotechnology, and peptide synthesis industries, enabling the production of complex molecules, drug conjugates, and functionalized materials with high efficiency.

Application

• Peptide Synthesis: A key reagent for the formation of peptide bonds in solid-phase and solution-phase synthesis.
• Bioconjugation: Used to crosslink proteins, antibodies, enzymes, and other biomolecules with labels, drugs, or solid supports for diagnostics and therapeutics.
• Polymer Chemistry: Facilitates the modification of polymers and the synthesis of polyamides and other functional materials.
• Carbohydrate Chemistry: Employed in the synthesis of glycoconjugates and the modification of sugars.
• Small Molecule Drug Development: Crucial for constructing amide linkages in the synthesis of active pharmaceutical ingredients (APIs) and intermediates.
• Material Science: Used for surface functionalization and creating bioactive coatings on various substrates.
• Antibody-Drug Conjugate (ADC) Production: A standard tool for linking cytotoxic payloads to monoclonal antibodies.
• Nucleic Acid Research: Applied in the modification and labeling of oligonucleotides.

Basic Information

Product Name	1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride
CAS No.	25952-53-8
Molecular Formula	C8H17N3·HCl
Molecular Weight	191.70 g/mol (Free base: 155.24 g/mol)
Synonyms	EDC Hydrochloride; EDAC HCl; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride; WSC Hydrochloride; Water-Soluble Carbodiimide Hydrochloride; 3-(Ethyliminomethyleneamino)-N,N-dimethylpropan-1-amine Hydrochloride; N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide Hydrochloride; 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide Hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing assay, impurity profile, and physical characteristics are provided with every shipment. We support compliance with cGMP, ISO, and other relevant quality standards for research and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent absorption of atmospheric moisture, which can degrade product performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	111 - 115 °C
Solubility	Freely soluble in water, methanol
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.