Description

1,1'-Oxalyldiimidazole is a versatile and highly reactive coupling agent and dehydrating reagent used in organic synthesis. Its primary value lies in its ability to efficiently activate carboxylic acids for the formation of amides, esters, and peptides under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries, where it facilitates the synthesis of complex molecules with high purity and yield.

Application

• Peptide Coupling Reagent: A key reagent for the formation of peptide bonds in solid-phase and solution-phase peptide synthesis.
• Carboxylic Acid Activation: Used to prepare active esters and anhydrides for subsequent nucleophilic substitution reactions.
• Esterification Catalyst: Facilitates ester formation between carboxylic acids and alcohols, often with reduced racemization.
• Polymer Chemistry: Employed in the synthesis of polyamides, polyesters, and other condensation polymers.
• Agrochemical Intermediate: Serves as a building block in the synthesis of active ingredients for crop protection products.
• Pharmaceutical Intermediate: Critical for constructing active pharmaceutical ingredients (APIs) and complex drug candidates.
• Reagent for Heterocyclic Synthesis: Used in the preparation of various imidazole and other nitrogen-containing heterocycles.

Basic Information

Product Name	1,1'-Oxalyldiimidazole
CAS No.	18637-83-7
Molecular Formula	C8H6N4O2
Molecular Weight	190.16 g/mol
Synonyms	ODI; Oxalyldiimidazole; N,N'-Oxalyldiimidazole; 1,1'-Oxalyldi-1H-imidazole; Oxalyl Diimidazole; 1H,1'H-[1,1']Biimidazolyl-1,1'-dione, 2,2'-(oxalyldiimino)bis-; 2,2'-(Oxalyldiimino)di(2H-imidazole); 1,1'-Carbonyldiimidazole related coupling agent.
EINECS	Contact for details

Quality Control

Our 1,1'-Oxalyldiimidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and production applications. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.