Description

n-Succinimidyl-n-Methylcarbamate CAS NO 18342-66-0 is a highly reactive, crystalline active ester reagent primarily used as a versatile linker and coupling agent in organic synthesis. Its core value lies in its ability to efficiently introduce the methylcarbamate protecting group or serve as a precursor for more complex functionalized molecules. This compound is essential for researchers and process chemists in the pharmaceutical, bioconjugation, and agrochemical industries who require reliable, high-purity building blocks for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation Reagent: Used for modifying proteins, peptides, and antibodies by introducing carbamate linkages.
• Polymer Chemistry: Serves as a functional monomer or cross-linking agent in the production of specialty polymers and hydrogels.
• Protecting Group Chemistry: Effective reagent for the temporary protection of amines via formation of methylcarbamate derivatives.
• Agrochemical Synthesis: Intermediate in the manufacture of certain herbicides and plant growth regulators.
• Material Science: Used in surface functionalization and the creation of advanced organic frameworks.
• Chemical Biology Probes: Utilized in the development of activity-based probes and diagnostic agents.

Basic Information

Product Name	n-Succinimidyl-n-Methylcarbamate
CAS No.	18342-66-0
Molecular Formula	C6H8N2O4
Molecular Weight	172.14 g/mol
Synonyms	N-Methylcarbamic Acid N-Hydroxysuccinimide Ester; N-Succinimidyl Methylcarbamate; NSC 334365; Methylcarbamic Acid Succinimidyl Ester; N-(N'-Methylcarbamoyloxy)succinimide; 1-[(Methylamino)carbonyloxy]-2,5-pyrrolidinedione; N-Hydroxysuccinimidyl N-Methylcarbamate
EINECS	Contact for details

Quality Control

Our n-Succinimidyl-n-Methylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.