Description

n-(9-Fluorenylmethoxycarbonyloxy)Succinimide is a highly specialized active ester reagent used for the introduction of the Fmoc protecting group. This compound matters as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for advanced synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the introduction of the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group onto amino acids.
• Oligonucleotide Synthesis: Used in the protection of exocyclic amines in nucleosides during automated DNA/RNA synthesis.
• Pharmaceutical Intermediates: Key starting material in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Facilitates the site-specific labeling and modification of peptides, proteins, and other biomolecules for research and diagnostics.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Academic & Industrial Research: Fundamental reagent for synthetic organic chemistry research focused on peptide mimetics and novel biomaterials.

Basic Information

Product Name	n-(9-Fluorenylmethoxycarbonyloxy)Succinimide
CAS No.	82911-69-1
Molecular Formula	C19H15NO5
Molecular Weight	337.33 g/mol
Synonyms	Fmoc-OSu; N-[(9H-Fluoren-9-ylmethoxy)carbonyloxy]succinimide; 9-Fluorenylmethyl N-succinimidyl carbonate; Fmoc-Osu; Fmoc-succinimide; N-Fmocoxysuccinimide; N-(9-Fluorenylmethoxycarbonyloxy)succinimide; N-Succinimidyl 9-fluorenylmethyl carbonate
EINECS	Contact for details

Quality Control

Our n-(9-Fluorenylmethoxycarbonyloxy)Succinimide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	149 - 153 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.