Description

Propylphosphonic Anhydride is a highly reactive organophosphorus reagent primarily used as a powerful coupling and dehydrating agent. Its core value lies in its exceptional efficiency for activating carboxylic acids, enabling the synthesis of amides, esters, and peptides under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it facilitates complex molecular transformations with high yields and minimal racemization.

Application

• Peptide Synthesis: As a potent coupling agent for the formation of peptide bonds in solid-phase and solution-phase synthesis.
• Amide & Ester Formation: For the efficient activation of carboxylic acids in the synthesis of amides, esters, and lactones.
• Pharmaceutical Intermediates: A key reagent in the production of active pharmaceutical ingredients (APIs) and complex drug molecules.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, insecticides, and plant growth regulators.
• Material Science: In the preparation of phosphorus-containing polymers, flame retardants, and specialty coatings.
• Chemical Research: As a versatile reagent for organic synthesis, particularly in reactions requiring anhydride activation.

Basic Information

Product Name	Propylphosphonic Anhydride
CAS No.	68957-94-8
Molecular Formula	C9H21O6P3
Molecular Weight	342.18 g/mol
Synonyms	Propylphosphonic Acid Anhydride; T3P® (Trade Name); Propylphosphonic Acid Cyclic Anhydride; n-Propylphosphonic Anhydride; 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide; 1,3,5-Tripropyl-1,3,5-trioxo-1,3,5-triphospha-2,4,6-trioxane; Ethylphosphonic Anhydride Homolog; PPG Reagent
EINECS	Contact for details

Quality Control

Our Propylphosphonic Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets requirement

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.