Description

Boc-Leu-Leu-Leu-Oh (CAS NO 18868-20-7) is a protected tripeptide derivative featuring a tert-butoxycarbonyl (Boc) N-terminal protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of longer, more complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of therapeutic peptides, protease substrates, and biochemical tools.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of longer therapeutic peptide sequences and peptidomimetics.
• Protease Research: Used as a substrate or inhibitor scaffold in the study of enzyme kinetics and mechanisms, particularly for leucine-specific proteases.
• Biochemical Tool Development: Serves as a precursor for fluorescent or tagged peptide probes used in cellular imaging and assay development.
• Academic & Industrial R&D: Fundamental reagent in organic chemistry and peptide science laboratories for method development and compound library synthesis.
• Custom Peptide Synthesis Services: A standard offering from CROs and CDMOs for clients requiring specific peptide fragments containing leucine residues.

Basic Information

Product Name	Boc-Leu-Leu-Leu-Oh
CAS No.	18868-20-7
Molecular Formula	C₂₁H₃₉N₃O₆
Molecular Weight	429.56 g/mol
Synonyms	Boc-L-Leu-L-Leu-L-Leucine; N-(tert-Butoxycarbonyl)-L-leucyl-L-leucyl-L-leucine; tert-Butyloxycarbonyl-Leu-Leu-Leu-OH; Boc-Leu-Leu-Leu; Boc-LLL-OH; (2S)-2-[[(2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoic acid; Nα-Boc-L-leucyl-L-leucyl-L-leucine; L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-
EINECS	Contact for details

Quality Control

Our Boc-Leu-Leu-Leu-Oh is produced under stringent conditions to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-40° to -44° (c=1, in AcOH)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Impurity (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.