Description

Biotin-Peg6-Oh CAS NO 906099-89-6 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin moiety on one terminus and a hydroxyl group on the other. This molecular design is critical for creating stable, site-specific conjugations in advanced bioconjugation and drug delivery platforms. It is an essential building block for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors who require precise and reliable linkers for developing targeted therapeutics, diagnostic probes, and affinity purification systems.

Application

• ADC (Antibody-Drug Conjugate) Development: Serves as a hydrophilic, flexible spacer to connect cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• Diagnostic Probe Conjugation: Used to attach biotin labels to antibodies, oligonucleotides, or other biomolecules for use in ELISA, lateral flow assays, and other detection systems leveraging streptavidin-biotin technology.
• Affinity Chromatography Ligand Synthesis: Functionalizes solid supports (e.g., agarose beads) to create resins for the purification of streptavidin/avidin-tagged proteins.
• Surface Functionalization: The hydroxyl group allows for further modification or attachment to surfaces and nanoparticles, creating biotinylated platforms for biosensor and microarray applications.
• Prodrug and Drug Delivery Systems: Acts as a biodegradable linker to attach targeting ligands (via biotin) to drug molecules or nanocarriers, enabling receptor-mediated delivery.
• Protein and Peptide Modification: Facilitates the site-specific biotinylation of proteins and peptides for structural studies, pull-down assays, and imaging.

Basic Information

Product Name	Biotin-Peg6-Oh
CAS No.	906099-89-6
Molecular Formula	C31H56N4O11S
Molecular Weight	692.86 g/mol
Synonyms	Biotin-PEG6-alcohol; Biotin-amido-PEG6-OH; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide; Biotin-PEG6-OH; Biotinylated PEG6 alcohol; Biotin-PEG6 linker; N-Biotinyl-3,6,9,12,15,18-hexaoxahenicosan-21-amide
EINECS	Contact for details

Quality Control

Our Biotin-Peg6-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for pharmaceutical research and bioconjugation. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.