Description

2'-Deoxy-5-Fluorouridine 5'-Phosphate Diammonium Salt is a key nucleotide analog intermediate, essential for research and development in targeted therapeutic areas. Its primary value lies in its role as a phosphorylated metabolite of the chemotherapeutic agent 5-Fluorouracil (5-FU), enabling studies into drug activation mechanisms and resistance. This high-purity compound is critically needed by pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers focused on oncology, antiviral agents, and molecular biology.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis and research of nucleoside-based chemotherapeutic and antiviral drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving thymidylate synthase, a key target in cancer therapy.
• Metabolite Standard: Serves as a certified reference standard in analytical laboratories for quantifying 5-FU and its active metabolites in pharmacokinetic and bioanalytical studies.
• Pro-drug Development: Investigated in the design of novel nucleotide pro-drugs aimed at improving cellular uptake and therapeutic efficacy.
• Diagnostic Reagent Manufacturing: Utilized in the production of kits and assays for cancer research and clinical diagnostics.

Basic Information

Product Name	2'-Deoxy-5-Fluorouridine 5'-Phosphate Diammonium Salt
CAS No.	99966-08-2
Molecular Formula	C9H17FN4O8P
Molecular Weight	368.23 g/mol
Synonyms	5-Fluoro-2'-deoxyuridine 5'-monophosphate diammonium salt; FdUMP diammonium salt; 5-Fluoro-2'-deoxyuridylic acid diammonium salt; 5-Fluorodeoxyuridine monophosphate diammonium salt; 5-FdUMP (NH4)2; NSC 27640 (diammonium salt); 2'-Deoxy-5-fluorouridine 5'-(dihydrogen phosphate) diammonium salt
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5-Fluorouridine 5'-Phosphate Diammonium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.