Description

Linoleic Acid, [9,10,12,13-3H] is a high-specific-activity, tritium-labeled form of the essential ω-6 fatty acid, linoleic acid. This labeled compound is critical for conducting precise metabolic and biochemical tracer studies where tracking the fate of linoleic acid is required. It is primarily utilized by researchers and scientists in pharmaceutical R&D, nutritional science, and lipid metabolism studies who require reliable, high-purity radiolabeled substrates for sensitive analytical techniques.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of linoleic acid in biological systems.
• Biochemical Research: Essential for investigating the enzymatic conversion of linoleic acid to bioactive metabolites like arachidonic acid and subsequent eicosanoids.
• Drug Discovery & Development: Employed in preclinical studies to understand the mechanism of action of drugs targeting lipid metabolism and inflammatory pathways.
• Nutritional Science Studies: Facilitates research into the essential fatty acid requirements, bioavailability, and functional roles of linoleic acid in diet and health.
• Analytical Method Development: Serves as an internal standard or reference material in the development and validation of sensitive LC-MS, GC-MS, and scintillation counting methods.
• Membrane Lipid Research: Used to study the incorporation and turnover of polyunsaturated fatty acids in cell membranes and lipid bilayers.

Basic Information

Product Name	Linoleic Acid, [9,10,12,13-3H]
CAS No.	99932-94-2
Molecular Formula	C18H293H3O2 *
Molecular Weight	~283.4 g/mol (varies with specific activity)
Synonyms	(9,10,12,13-3H)Linoleic Acid; Tritiated Linoleic Acid; [3H]-Linoleic Acid; cis,cis-9,12-Octadecadienoic-9,10,12,13-3H acid; Linoleic Acid-9,10,12,13-t4; (9Z,12Z)-9,12-Octadecadienoic-9,10,12,13-3H Acid; Vitamin F (labeled); Radiolabeled Linoleic Acid
EINECS	Contact for details

* Formula represents the general structure with tritium atoms at the specified positions.

Quality Control

Every batch of Linoleic Acid, [9,10,12,13-3H] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards for radiolabeled compounds. Certificates of Analysis (COA) are provided, detailing key parameters such as radiochemical purity, chemical purity, specific activity, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. For long-term storage, keep under an inert atmosphere (argon or nitrogen) to minimize oxidation. This product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Users must follow all applicable radiation safety guidelines and regulations for handling, storage, and disposal.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (IR/NMR)	Conforms to structure
Specific Activity	30-100 Ci/mmol (Contact for specific value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC/GC)	≥ 95%
Concentration	1.0 mCi/mL (in ethanol or toluene, as specified)
Solvent	Ethanol or Toluene (as per COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.