Description

Rhodamine 110, (Sar-Pro-Arg)(2) is a specialized, high-purity peptide-conjugated derivative of the classic Rhodamine 110 fluorophore. This compound matters for researchers and developers requiring a highly specific, fluorescently tagged substrate for sensitive enzymatic assays, particularly in protease research. It is primarily needed by biotechnology, pharmaceutical R&D, and diagnostic kit manufacturers focused on studying enzyme kinetics, high-throughput screening, and developing novel biochemical detection methods.

Application

• Fluorescent Protease Substrate: A critical reagent for the continuous, real-time monitoring of protease activity, including trypsin, thrombin, and other serine proteases.
• Biochemical Assay Development: Used in designing and optimizing sensitive in vitro diagnostic (IVD) and research-use-only (RUO) assays for enzymatic function.
• High-Throughput Screening (HTS): Enables the screening of large compound libraries for potential protease inhibitors or activators in drug discovery pipelines.
• Cell Biology Research: Applied in studies of intracellular proteolytic processes and signal transduction pathways when used with appropriate delivery systems.
• Diagnostic Manufacturing: Serves as a key component in the production of clinical diagnostic tests that measure specific protease levels as disease biomarkers.

Basic Information

Product Name	Rhodamine 110, (Sar-Pro-Arg)(2)
CAS No.	99815-08-4
Molecular Formula	C52H68N14O10
Molecular Weight	1025.19 g/mol
Synonyms	R110-(Sar-Pro-Arg)2; Bis-(Sar-Pro-Arg) Rhodamine 110; Rhodamine 110 bis-(sarcosyl-prolyl-arginine) amide; (Sar-Pro-Arg)2-R110; Protease Substrate R110; Fluorogenic Peptide Substrate R110; Thrombin Substrate R110; Trypsin Substrate R110
EINECS	Contact for details

Quality Control

Our Rhodamine 110, (Sar-Pro-Arg)(2) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for sensitive biochemical applications. Certificates of Analysis (COA) detailing purity, performance in standard assays, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Performance (Enzymatic Assay)	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.