Description

8-(5-Thioacetamidofluorescein)Cyclic-Gmp is a specialized, high-purity biochemical reagent designed for advanced research applications. This compound matters as a critical tool for studying intracellular signaling pathways, particularly those involving cyclic guanosine monophosphate (cGMP). Researchers in pharmaceutical development and life sciences need it for sensitive detection and quantification assays, including fluorescence-based imaging and high-throughput screening.

Application

• Biochemical Research: As a fluorescently-labeled cGMP derivative for investigating cyclic nucleotide signaling cascades.
• Enzyme Assay Development: Serving as a substrate or probe for studying phosphodiesterase (PDE) activity and kinetics.
• Cellular Imaging: Utilization in fluorescence microscopy to visualize and track cGMP dynamics within live cells.
• Diagnostic Kit Manufacturing: A key component in the development of sensitive immunoassays and diagnostic tests for research use.
• High-Throughput Screening (HTS): Enabling the discovery of novel drug candidates that modulate cGMP-related pathways.
• Signal Transduction Studies: Probing the role of cGMP in physiological processes such as vasodilation, phototransduction, and neural function.

Basic Information

Product Name	8-(5-Thioacetamidofluorescein)Cyclic-Gmp
CAS No.	99776-42-8
Molecular Formula	C38H33N7O11S2
Molecular Weight	851.84 g/mol
Synonyms	8-(5-Thioacetamidofluorescein)-cGMP; Fluorescein-cGMP; 8-Fluorescein-cGMP; 8-(5-TAFC)-cGMP; cGMP, 8-(5-thioacetamidofluorescein)-; Fluorescent cGMP derivative; Thioacetamidofluorescein labeled cyclic GMP; cGMP-fluorescein conjugate
EINECS	Contact for details

Quality Control

Our 8-(5-Thioacetamidofluorescein)Cyclic-Gmp is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic identification. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Extinction Coefficient	Contact for details
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.