Description

D-Mannitol-(1-3H(N)) is a tritium-labeled isotopologue of the sugar alcohol D-Mannitol, a critical tool for metabolic and pharmacokinetic research. This labeled compound enables precise tracing and quantification of mannitol in complex biological systems, providing invaluable data on absorption, distribution, metabolism, and excretion (ADME). It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors who require high-specific-activity tracers for advanced analytical studies.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the metabolic fate and pharmacokinetics of mannitol in preclinical and clinical research.
• Drug Development & ADME Studies: Critical for Absorption, Distribution, Metabolism, and Excretion (ADME) profiling of pharmaceutical formulations containing mannitol.
• Biochemical Research: Employed in enzyme assays and studies of osmotic regulation and cellular transport mechanisms.
• Analytical Method Development: Serves as an internal standard or reference material in the development and validation of sensitive analytical methods like LC-MS and scintillation counting.
• Quality Control & Stability Testing: Used in pharmaceutical QC labs to study the stability and degradation pathways of mannitol-containing drug products.

Basic Information

Product Name	D-Mannitol-(1-3H(N))
CAS No.	99745-65-0
Molecular Formula	C6H133HO6
Molecular Weight	~184.16 g/mol (for 3H labeled)
Synonyms	Mannitol-1-t; (3H)Mannitol; 1-Tritio-D-mannitol; D-Mannitol-1-t; Tritium-labeled D-Mannitol; [1-3H]-D-Mannitol; Mannitol (1-tritiated); Hexane-1,2,3,4,5,6-hexol-1-t
EINECS	Contact for details

Quality Control

Every batch of D-Mannitol-(1-3H(N)) is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters such as radiochemical purity, specific activity, chemical purity, and solvent content. Our quality commitment ensures the material meets the stringent requirements for research-grade radioactive tracers, supporting reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold temperatures (e.g., -20°C or as specified on the label) to maintain stability and minimize radiolytic decomposition. Due to its labeled nature and potential volatility, store upright in appropriate shielding and in accordance with all local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR/NMR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	Customizable (Ci/mmol range)
Chemical Purity (HPLC/GC)	≥ 98%
Solvent	Ethanol/Water or as specified
Concentration	1 mCi/mL (or as customized)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.