Description

Ondansetron CAS NO 99614-58-1 is a highly selective serotonin 5-HT3 receptor antagonist. This compound is critically important for its potent antiemetic properties, effectively preventing nausea and vomiting. It is an essential active pharmaceutical ingredient (API) primarily needed by pharmaceutical manufacturers for the production of injectable and oral formulations used in chemotherapy, radiotherapy, and post-operative care.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiemetic medications.
• Chemotherapy-Induced Nausea and Vomiting (CINV): Formulated into injectable solutions and oral tablets for prophylaxis and treatment.
• Radiotherapy-Induced Nausea and Vomiting: Key component in therapeutic regimens for cancer patients.
• Post-Operative Nausea and Vomiting (PONV): Used in hospital settings for patient recovery management.
• Generic Drug Manufacturing: Sourced by generic pharmaceutical companies for cost-effective production.
• Research & Development: Used in preclinical and clinical studies for new antiemetic formulations.
• Veterinary Medicine: Potential application in managing emesis in animals under specific treatments.

Basic Information

Product Name	Ondansetron
CAS No.	99614-58-1
Molecular Formula	C18H19N3O
Molecular Weight	293.37 g/mol
Synonyms	1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one; GR 38032F; Zofran; SN 307; (±)-Ondansetron; NSC 759108; UNII-4AF302ESOS
EINECS	Contact for details

Quality Control

Our Ondansetron is manufactured under strict quality systems. We ensure compliance with major pharmacopoeial standards, including USP and EP monographs. Every batch undergoes rigorous analytical testing for identity, purity, and impurity profiles using validated methods. Certificates of Analysis (COA) documenting full specifications are available upon request to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Specific Optical Rotation	-14° to -18° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.