Description

(9-Cis,13-Cis)-12-Carboxy Retinoic Acid is a specific geometric isomer of a carboxylic acid derivative of retinoic acid, offering distinct biological activity and chemical properties. This high-purity compound is critical for advanced research in cell signaling and differentiation pathways, particularly those mediated by retinoid receptors. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on developing novel therapeutics and biochemical tools.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel retinoid-based therapies.
• Biochemical Research: Used as a potent ligand in studies of retinoid receptor (RAR/RXR) binding affinity, specificity, and downstream gene expression effects.
• Cell Biology Studies: Employed to investigate the role of specific retinoic acid isomers in cellular processes like proliferation, differentiation, and apoptosis.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Fine Chemical Synthesis: Acts as a sophisticated building block for the synthesis of more complex retinoid analogs and prodrugs.

Basic Information

Product Name	(9-Cis,13-Cis)-12-Carboxy Retinoic Acid
CAS No.	99394-38-4
Molecular Formula	C20H28O4
Molecular Weight	332.43 g/mol
Synonyms	9-cis,13-cis-12-Carboxyretinoic Acid; (9Z,13Z)-Retinoic Acid-12-carboxylic Acid; 12-Carboxy-9-cis,13-cis-retinoic Acid; 9,13-di-cis-12-Carboxyretinoic Acid; 9Z,13Z-12-Carboxyretinoic Acid; Retinoic Acid-12-carboxylic Acid (9-cis,13-cis-isomer); 12-COOH-9-cis,13-cis-RA
EINECS	Contact for details

Quality Control

Our (9-Cis,13-Cis)-12-Carboxy Retinoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and isomer specificity, NMR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and ensure long-term stability. The container should be kept in a dry, cool, and well-ventilated area. Allow the product to reach room temperature in the sealed container before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isomeric Purity (HPLC)	≥ 95.0% (9-cis,13-cis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.