Description

2-Fluoro-2-Deoxy-6-Phosphogluconate is a fluorinated sugar phosphate derivative, a key biochemical intermediate used in metabolic pathway studies. This compound matters for its role as a potent inhibitor of the enzyme 6-phosphogluconate dehydrogenase (6PGD), enabling critical research into the oxidative pentose phosphate pathway. It is primarily needed by biochemical and pharmaceutical research institutions, as well as diagnostic kit manufacturers, for investigating cancer metabolism, enzyme kinetics, and developing novel therapeutic strategies.

Application

• Biochemical Research: As a specific and potent inhibitor of 6-phosphogluconate dehydrogenase (6PGD) for studying the oxidative pentose phosphate pathway (PPP).
• Cancer Metabolism Studies: Used to investigate tumor cell metabolism, proliferation, and redox balance by blocking a key NADPH-producing enzyme.
• Enzyme Kinetics & Mechanism: Serves as a substrate analog for detailed enzymatic studies, inhibition assays, and determining kinetic parameters.
• Diagnostic Reagent Development: A potential component in enzymatic assay kits for research and clinical diagnostics targeting metabolic disorders.
• Pharmaceutical R&D: Used in high-throughput screening and target validation for drug discovery programs focused on metabolic diseases and oncology.
• Metabolic Pathway Analysis: A tool for elucidating carbon flux and regulatory mechanisms in central carbon metabolism within cell biology.

Basic Information

Product Name	2-Fluoro-2-Deoxy-6-Phosphogluconate
CAS No.	99257-07-5
Molecular Formula	C6H11FO11P
Molecular Weight	278.12 g/mol
Synonyms	2-Fluoro-2-deoxy-D-gluconate 6-phosphate; 2-F-2-dG6P; 2-Fluoro-6-phosphogluconate; 6-Phospho-2-fluoro-2-deoxygluconate; 6PGD Inhibitor; (2R,3S,4R,5R)-2-Fluoro-3,4,5-trihydroxy-6-(phosphonooxy)hexanoic acid; FDG6P; 2-Fluoro-2-deoxygluconic acid 6-phosphate
EINECS	Contact for details

Quality Control

Our 2-Fluoro-2-Deoxy-6-Phosphogluconate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.