Description

(+/-)-8-Hydroxy-5Z,9E,11Z,14Z,17Z-Eicosapentaenoic Acid CAS NO 99217-77-3 is a specialized hydroxy fatty acid derivative of eicosapentaenoic acid (EPA), a key ω-3 fatty acid. This compound is of significant interest as a bioactive lipid mediator and a valuable reference standard in metabolic and inflammation research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics and analytical methods for lipidomics.

Application

• Biochemical Research: Used as a critical reference standard and analytical tool in lipidomics and metabolomics studies to understand eicosanoid and oxylipin pathways.
• Pharmaceutical R&D: Serves as a key intermediate or reference compound in the development of novel anti-inflammatory and pro-resolving drug candidates targeting lipid mediator pathways.
• Inflammation Studies: Employed in cellular and in vitro assays to investigate the role of hydroxy-EPA derivatives in inflammatory processes and resolution mechanisms.
• Analytical Chemistry: Essential for method development, validation, and calibration in advanced analytical techniques like LC-MS/MS and HPLC for accurate quantification of oxylipins.
• Nutritional Science Research: Used to study the metabolic fate and bioactive derivatives of dietary ω-3 fatty acids like EPA.

Basic Information

Product Name	(+/-)-8-Hydroxy-5Z,9E,11Z,14Z,17Z-Eicosapentaenoic Acid
CAS No.	99217-77-3
Molecular Formula	C₂₀H₃₀O₃
Molecular Weight	318.45 g/mol
Synonyms	8-HEPE; 8-Hydroxy-EPA; 8-Hydroxyeicosapentaenoic Acid; (±)-8-Hydroxy-5Z,9E,11Z,14Z,17Z-eicosapentaenoic Acid; 8-Hydroxy-5Z,9E,11Z,14Z,17Z-eicosapentaenoic Acid; 8(S)-HEPE; 8(R)-HEPE (racemic mixture); 8-Hydroxy-5,9,11,14,17-eicosapentaenoic Acid
EINECS	Contact for details

Quality Control

Our high-purity biochemicals are produced and handled under strict quality management protocols. Each batch of (+/-)-8-Hydroxy-5Z,9E,11Z,14Z,17Z-Eicosapentaenoic Acid undergoes rigorous analytical testing, including HPLC and mass spectrometry, to ensure identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Area %)
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.