Description

1-o-Hexadecyl-2-Acetyl-Sn-Glycero-3 is a high-purity synthetic phospholipid derivative, specifically a lysophospholipid analog. This compound is a critical intermediate and building block in advanced lipid research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences, particularly for the synthesis of novel drug delivery systems, lipid nanoparticles (LNPs), and as a standard in analytical chemistry.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural component for constructing stable, biocompatible carriers for mRNA, siRNA, and other nucleic acid therapeutics.
• Phospholipid Research & Synthesis: Serves as a versatile precursor or intermediate in the chemical and enzymatic synthesis of more complex phospholipids and their analogs.
• Membrane Biophysics Studies: Used to study lipid bilayer properties, membrane fluidity, and protein-lipid interactions in model membrane systems.
• Drug Delivery Vehicle Development: Incorporated into liposomes, micelles, and other nanocarriers to enhance drug solubility, targeting, and controlled release profiles.
• Analytical Reference Standard: Employed as a high-purity standard in chromatographic (HPLC, LC-MS) and spectroscopic analyses for quality control and method development.
• Bioconjugation & Probe Synthesis: Functionalized with fluorescent dyes, targeting ligands, or other moieties to create specialized probes for cellular imaging and diagnostics.

Basic Information

Product Name	1-o-Hexadecyl-2-Acetyl-Sn-Glycero-3
CAS No.	99103-16-9
Molecular Formula	C₂₁H₄₂O₅
Molecular Weight	374.56 g/mol
Synonyms	1-O-Hexadecyl-2-acetyl-sn-glycerol; 1-O-Hexadecyl-2-acetyl-rac-glycerol; 2-Acetyl-1-O-hexadecylglycerol; 1-Hexadecyl-2-acetyl-sn-glycerol; 1-Cetyl-2-acetyl-sn-glycerol; 1-O-Cetyl-2-acetyl-sn-glycerol; 2-Acetyl-1-O-cetylglycerol; rac-1-O-Hexadecyl-2-acetylglycerol
EINECS	Contact for details

Quality Control

Our 1-o-Hexadecyl-2-Acetyl-Sn-Glycero-3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements of research and pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to minimize moisture uptake. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid/waxy solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.