Description

2-Azido-N(6)-4-Hydroxyphenylisopropyladenosine is a chemically modified adenosine derivative, specifically designed as a potent and selective agonist for adenosine receptors. This compound is a critical research tool for investigating cellular signaling pathways, receptor pharmacology, and the role of adenosine in various physiological and pathological processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and development for conditions related to cardiovascular, neurological, and inflammatory diseases.

Application

• Pharmacological Research: As a key reference standard and agonist in studies targeting adenosine A1, A2A, and A3 receptor subtypes.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and characterize novel therapeutic compounds for cardiovascular and CNS disorders.
• Biochemical Assays: Employed in in vitro and cell-based assays to study G-protein coupled receptor (GPCR) activation, cAMP modulation, and downstream signaling events.
• Academic Research: A vital reagent for fundamental research into the role of adenosine in ischemia-reperfusion injury, neuroprotection, and immune modulation.
• Chemical Biology: The azido functional group allows for potential use in click chemistry applications for labeling or conjugating the molecule to probes or other biomolecules.
• Reference Material: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	2-Azido-N(6)-4-Hydroxyphenylisopropyladenosine
CAS No.	98897-11-1
Molecular Formula	C19H21N9O4
Molecular Weight	439.43 g/mol
Synonyms	2-Azido-N6-(4-Hydroxyphenylisopropyl)adenosine; 2-Azido-N6-(4-Hydroxybenzyl)adenosine derivative; 2-N3-N6-(4-Hydroxyphenylisopropyl)adenosine; HIT-agonists series compound; Adenosine receptor agonist; 2-Azido-ARA derivative; 2-Azido-N6-(3-(4-Hydroxyphenyl)isopropyl)adenosine; 2-Azido-N6-(R-phenylisopropyl)adenosine analog
EINECS	Contact for details

Quality Control

Our 2-Azido-N(6)-4-Hydroxyphenylisopropyladenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our commitment to quality and consistency supports reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.