Description

N(6)-(3-Iodo-4-Azidobenzyl)Adenosine is a specialized, bifunctional chemical probe designed for photoaffinity labeling and cross-linking studies. This compound matters for researchers requiring precise, covalent attachment to biological targets, combining an adenosine moiety for binding with photoreactive and click-chemistry handles for detection. It is primarily needed by scientists in pharmaceutical R&D, chemical biology, and proteomics for investigating nucleotide-binding proteins, enzyme mechanisms, and protein-ligand interactions.

Application

• Photoaffinity Labeling Probe: Used to covalently tag and identify adenosine-binding sites on proteins and enzymes upon UV light activation.
• Chemical Biology Research: Serves as a key reagent for studying purinergic signaling pathways and adenosine receptor interactions.
• Proteomics and Target Identification: Enables the isolation and characterization of unknown protein targets through its azide group for subsequent bioconjugation via click chemistry.
• Enzyme Mechanism Studies: Acts as an activity-based probe for nucleoside-processing enzymes, aiding in inhibitor design and kinetic analysis.
• Bioconjugation and Linker Chemistry: The iodo and azido functional groups allow for versatile conjugation to other molecules, surfaces, or fluorophores.
• Diagnostic Assay Development: Potential use in developing assays for high-throughput screening of ligands for adenosine-binding proteins.

Basic Information

Product Name	N(6)-(3-Iodo-4-Azidobenzyl)Adenosine
CAS No.	98849-99-1
Molecular Formula	C₁₇H₁₆IN₇O₄
Molecular Weight	509.26 g/mol
Synonyms	N6-(3-Iodo-4-azidobenzyl)adenosine; 6-[(3-Iodo-4-azidophenyl)methyl]amino]-9-β-D-ribofuranosyl-9H-purine; 3-Iodo-4-azidobenzyl-adenosine; N6-(3-Iodo-4-azidobenzyl)adenosine; Adenosine, N-[ (3-iodo-4-azidophenyl)methyl]-; Photoaffinity Labeling Adenosine Derivative
EINECS	Contact for details

Quality Control

Our N(6)-(3-Iodo-4-Azidobenzyl)Adenosine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your experimental workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated place away from heat and incompatible materials. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.