Description

Dmt-Da(Bz) Phosphoramidite is a high-purity, nucleoside phosphoramidite monomer essential for automated oligonucleotide synthesis. This compound is a critical building block for the solid-phase synthesis of DNA and RNA strands, enabling precise control over genetic sequence construction. It is primarily required by biotechnology, pharmaceutical, and diagnostic industries for applications in therapeutic development, genetic research, and molecular diagnostics. The product is supplied under stringent quality control to ensure optimal coupling efficiency and yield in synthesis protocols.

Application

• Oligonucleotide Synthesis: A key monomer for the automated solid-phase synthesis of DNA and RNA sequences.
• Therapeutic Development: Used in the production of antisense oligonucleotides, siRNA, and aptamers for novel drug modalities.
• Genetic Research & Diagnostics: Essential for creating probes, primers, and gene fragments used in PCR, sequencing, and genetic testing.
• Synthetic Biology: Enables the construction of custom genes and regulatory elements for engineered biological systems.
• Bioconjugation & Labeling: Serves as an intermediate for introducing modified bases or functional groups into oligonucleotides.
• Academic & Industrial R&D: A fundamental reagent for laboratories conducting cutting-edge research in molecular biology and biochemistry.

Basic Information

Product Name	Dmt-Da(Bz) Phosphoramidite
CAS No.	98796-53-3
Molecular Formula	C41H49N6O7P
Molecular Weight	760.85 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-dA(Bz)-CE Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); dA(Bz) Phosphoramidite; 2'-Deoxyadenosine, N6-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)
EINECS	Contact for details

Quality Control

Our Dmt-Da(Bz) Phosphoramidite is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to industry best practices and can provide material tailored to meet specific customer requirements or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Moisture Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.