Description

Aminopterin n-Hydroxysuccinimide Ester is a high-purity, activated ester derivative of the classical antifolate agent, Aminopterin. This compound is critically important as a key intermediate for the synthesis of targeted drug conjugates and antibody-drug conjugates (ADCs), enabling precise delivery of cytotoxic payloads. It is primarily needed by pharmaceutical R&D teams, bioconjugation specialists, and manufacturers in the oncology and immunology sectors developing next-generation targeted therapies.

Application

• Antibody-Drug Conjugate (ADC) Payload Linker: Serves as a critical building block for conjugating cytotoxic aminopterin derivatives to monoclonal antibodies via lysine residues.
• Targeted Cancer Therapy Development: Used in research and pre-clinical development of novel chemotherapeutic agents designed for specific tumor targeting.
• Bioconjugation & Protein Labeling: Facilitates the covalent attachment of aminopterin to proteins, peptides, or other biomolecules for activity studies or diagnostic applications.
• Enzyme Inhibition Studies: Employed to create irreversible or high-affinity inhibitors of dihydrofolate reductase (DHFR) for mechanistic biochemical research.
• Pharmaceutical Intermediate: Acts as a specialized intermediate in the multi-step synthesis of advanced, folate-targeted pharmaceutical compounds.
• Immunology Research: Used in the development of immunomodulatory agents and studies involving folate receptor-expressing cells.

Basic Information

Product Name	Aminopterin n-Hydroxysuccinimide Ester
CAS No.	98457-88-6
Molecular Formula	C₂₀H₁₈N₆O₆
Molecular Weight	438.40 g/mol
Synonyms	NHS-Aminopterin; Aminopterin N-Hydroxysuccinimide Ester; Aminopterin Active Ester; 4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoic Acid N-Hydroxysuccinimide Ester; Aminopterin NHS Ester; Aminopterin-OSu; NSC 73909; Aminopterin Succinimidyl Ester
EINECS	Contact for details

Quality Control

Our Aminopterin n-Hydroxysuccinimide Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.