Description

Thymidine 5'-Monophosphate p-Nitrophenyl Ester Sodium Salt is a key nucleotide derivative used as a specialized substrate and building block in biochemical research and synthesis. This compound is valued for its role in enzymatic assays and the study of nucleic acid metabolism, where the p-nitrophenyl ester group serves as a chromogenic leaving group. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, molecular biology, and diagnostic reagent production.

Application

• Enzymatic Substrate: Used as a chromogenic substrate for phosphatases, nucleotidases, and other enzymes that cleave phosphate esters, enabling kinetic studies and high-throughput screening.
• Nucleic Acid Research: Serves as a precursor or modified nucleotide in studies of DNA/RNA synthesis, repair mechanisms, and nucleotide analog development.
• Diagnostic Reagent Manufacturing: Incorporated into kits and reagents for clinical diagnostics and biochemical testing that measure enzymatic activity.
• Pharmaceutical Intermediate: Acts as a specialized building block in the synthesis of antiviral or anticancer prodrugs and other nucleotide-based therapeutics.
• Biochemical Tool Development: Utilized in designing probes and assays for studying cellular signaling pathways involving nucleotide turnover.

Basic Information

Product Name	Thymidine 5'-Monophosphate p-Nitrophenyl Ester Sodium Salt
CAS No.	98179-10-3
Molecular Formula	C16H17N3O10PNa2 or C16H18N3O10PNa (Contact for details)
Molecular Weight	Approx. 495.3 g/mol (Contact for details)
Synonyms	p-Nitrophenyl Thymidine 5'-Monophosphate Sodium Salt; Thymidine 5'-(p-Nitrophenyl Phosphate) Sodium Salt; TMP p-Nitrophenyl Ester Sodium Salt; 5'-TMP-PNP Na Salt; pNPP-TMP Na; p-Nitrophenyl TMP; Thymidine 5'-monophosphate 4-nitrophenyl ester sodium salt; 4-Nitrophenyl thymidine 5'-phosphate sodium salt
EINECS	Contact for details

Quality Control

Our Thymidine 5'-Monophosphate p-Nitrophenyl Ester Sodium Salt is produced and tested under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.