Description

N(2)-Methyl-8-oxoguanine is a modified nucleobase derivative of guanine, featuring a methyl group at the N(2) position and an oxo group at the C8 position. This specific molecular structure makes it a valuable intermediate and reference standard in advanced biochemical and pharmaceutical research. It is primarily sought after by research institutions and companies engaged in nucleic acid chemistry, epigenetics, and the development of novel therapeutic agents. The compound's role in studying DNA damage, repair mechanisms, and as a building block for modified oligonucleotides underscores its importance in modern life sciences.

Application

• Biochemical Research: Used as a critical reference standard and intermediate in studies of oxidative DNA damage and repair pathways.
• Pharmaceutical Development: Serves as a key building block in the synthesis of novel nucleoside analogs for potential antiviral or anticancer therapies.
• Epigenetics & Molecular Biology: Employed in research exploring the role of modified DNA bases in gene expression and cellular regulation.
• Diagnostic Reagent Synthesis: Utilized in the production of probes and reagents for detecting specific DNA lesions or modifications.
• Academic Research: A fundamental tool for universities and research institutes focusing on nucleic acid chemistry and toxicology.
• Contract Research Organizations (CROs): Supplied to CROs conducting client-sponsored research on genotoxicity and mutagenicity.

Basic Information

Product Name	N(2)-Methyl-8-oxoguanine
CAS No.	98141-17-4
Molecular Formula	C₆H₇N₅O₂
Molecular Weight	181.15 g/mol
Synonyms	8-Oxo-N(2)-methylguanine; 2-Methylamino-6,8-dihydroxypurine; N2-Methyl-8-oxoguanine; 8-Oxo-2-methylaminopurine; 2-Methyl-8-oxoguanine; 8-Hydroxy-2-(methylamino)purin-6(1H)-one; Guanine, N(2)-methyl-8-oxo-; 6,8-Dihydroxy-2-(methylamino)purine
EINECS	Contact for details

Quality Control

Our N(2)-Methyl-8-oxoguanine is manufactured under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.