Description

(n-(Chloroacetylamino)-3,5-Dihydroxy-2-Morpholinyl)Methyl Guanosine Triphosphate is a chemically modified nucleotide analog designed for advanced biochemical research and pharmaceutical development. This compound is critical for studying and manipulating cellular signaling pathways, particularly those involving G-proteins and nucleotide-dependent enzymes. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in high-throughput screening, enzymology, and the development of novel therapeutic agents.

Application

• Biochemical Research: As a substrate or inhibitor in enzymatic assays to study GTPase activity and related signal transduction mechanisms.
• Pharmaceutical Development: Used in high-throughput screening (HTS) campaigns to identify potential drug candidates targeting G-protein-coupled receptors (GPCRs).
• Molecular Biology: A tool compound for investigating the structure and function of nucleotide-binding proteins and enzymes.
• Diagnostic Reagent Manufacturing: A key component in the formulation of specialized diagnostic kits for cellular pathway analysis.
• Proteomics & Cell Signaling Studies: Employed to label, track, or modulate specific protein interactions within complex cellular networks.
• Antiviral & Anticancer Research: Investigated for its potential role in disrupting viral replication or aberrant cell signaling in oncology research.

Basic Information

Product Name	(n-(Chloroacetylamino)-3,5-Dihydroxy-2-Morpholinyl)Methyl Guanosine Triphosphate
CAS No.	98104-37-1
Molecular Formula	C₁₇H₂₅ClN₇O₁₅P₃
Molecular Weight	719.81 g/mol
Synonyms	GTP, γ-[2-(Morpholin-4-yl)-2-oxoethyl]amide, chloroacetyl derivative; Chloroacetyl-GTP morpholino derivative; 2'- (or 3')-O-(N-(Chloroacetyl)-2-amino-2-deoxy-α/β-D-glucopyranosyl)guanosine 5'-triphosphate (related analog); Modified GTP analog; Nucleotide probe; GTP-γ-Morpholino Chloroacetamide; Signal transduction inhibitor precursor
EINECS	Contact for details

Quality Control

Our (n-(Chloroacetylamino)-3,5-Dihydroxy-2-Morpholinyl)Methyl Guanosine Triphosphate is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.