Description

2-((4-Bromo-2,3-Dioxobutyl)Thio)-1,N(6)-Ethenoadenosine 2',5'-Bisphosphate is a chemically modified adenosine nucleotide derivative, serving as a critical biochemical tool and research reagent. This compound is valued for its role as a potent and selective inhibitor of cyclic nucleotide phosphodiesterases, enabling precise investigation of cyclic AMP (cAMP) signaling pathways. It is primarily utilized by researchers and developers in the fields of pharmacology, molecular biology, and neuroscience for studying cellular regulation and developing novel therapeutic agents.

Application

• Biochemical Research: As a high-affinity inhibitor for studying cyclic nucleotide phosphodiesterase (PDE) enzyme activity and kinetics.
• Pharmacological Studies: Used in target validation and mechanism-of-action studies for diseases involving cAMP signaling dysregulation.
• Neuroscience Research: Investigation of cAMP's role in neuronal function, synaptic plasticity, and memory formation.
• Cell Signaling Pathway Analysis: A key tool for modulating intracellular cAMP levels to dissect downstream effects in various cell types.
• Drug Discovery & Development: Serves as a reference compound and lead structure for designing new PDE-targeted pharmaceuticals.
• Diagnostic Kit Development: Potential use in assay development for measuring PDE activity in clinical or research samples.

Basic Information

Product Name	2-((4-Bromo-2,3-Dioxobutyl)Thio)-1,N(6)-Ethenoadenosine 2',5'-Bisphosphate
CAS No.	98088-69-8
Molecular Formula	C₁₇H₁₉BrN₅O₁₂P₂S
Molecular Weight	683.27 g/mol
Synonyms	2-[(4-Bromo-2,3-dioxobutyl)thio]-1,N6-ethenoadenosine 2',5'-bisphosphate; 2-((4-Bromo-2,3-dioxobutyl)thio)-1,N6-ethenoadenosine-2',5'-bisphosphate; 2',5'-Bisphospho-1,N6-etheno-2-((4-bromo-2,3-dioxobutyl)thio)adenosine; 2',5'-Bisphosphoadenosine 1,N6-etheno-2-((4-bromo-2,3-dioxobutyl)thio); PDE Inhibitor; cAMP PDE Inhibitor; 1,N6-Etheno-cAMP analogue
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting your research reproducibility and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is moisture-sensitive; keep the container tightly sealed in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.