Description

Streptolysin O CAS NO 98072-47-0 is a potent, oxygen-labile cytolytic exotoxin produced by Group A *Streptococcus* bacteria. This protein is a critical reagent in clinical diagnostics and immunological research, primarily used to detect anti-streptolysin O (ASO) antibodies in human serum. It serves as an essential component for in vitro diagnostic kits and fundamental studies in microbiology, immunology, and bacterial pathogenesis. Industries requiring precise immunological assays, including clinical diagnostics, pharmaceutical R&D, and academic research, rely on high-purity, well-characterized Streptolysin O for accurate and reproducible results.

Application

• Clinical Diagnostics: As the core antigen in Anti-Streptolysin O (ASO) latex agglutination and turbidimetric tests for diagnosing recent streptococcal infections (e.g., rheumatic fever, post-streptococcal glomerulonephritis).
• Immunological Research: Used to study host immune response, toxin mechanisms, and pore-forming protein behavior in cell membranes.
• In Vitro Diagnostic (IVD) Kit Manufacturing: A key raw material for the production of commercial diagnostic test kits and calibrators.
• Cell Biology Studies: Employed as a tool for reversible plasma membrane permeabilization to introduce molecules into cells.
• Vaccine & Therapeutic Development: Used in research for developing vaccines or anti-toxin therapies against streptococcal diseases.
• Quality Control & Standardization: Serves as a reference standard for lot-to-lot consistency testing in diagnostic reagent production.

Basic Information

Product Name	Streptolysin O
CAS No.	98072-47-0
Molecular Formula	Contact for details
Molecular Weight	~69 kDa (Protein)
Synonyms	Streptolysin O; SLO; ASO Antigen; Streptococcal Hemolysin O; Oxygen-Labile Streptolysin; EC 3.1.4.41; Cholesterol-dependent cytolysin
EINECS	Contact for details

Quality Control

Our Streptolysin O is manufactured and tested under a rigorous quality management system. Each lot is characterized for critical parameters including biological activity (hemolytic units), purity, and specificity to ensure optimal performance in diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by SDS-PAGE/HPLC), protein concentration, sterility, and functional activity is provided with every shipment to guarantee lot-to-lot consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C or below to prevent activity loss. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Immunological)	Positive reaction with standard ASO-positive serum
Purity (SDS-PAGE)	≥ 90%
Protein Content (Biuret/BCA)	≥ 90% of stated weight
Specific Activity (Hemolytic Units/mg)	≥ 1 x 10⁶ HU/mg protein
Sterility (Membrane Filtration)	Sterile
Endotoxin (LAL)	< 10 EU/mg
Moisture Content (Karl Fischer)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.