Description

Boc-Lys(Tfa)-Amc CAS NO 97885-44-4 is a specialized, protected amino acid derivative widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates for the development of novel pharmaceuticals and biochemical probes. It is primarily utilized by professionals in pharmaceutical R&D, biotechnology, and fine chemical synthesis for creating complex peptide-based molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of lysine residues into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including potential therapeutics for metabolic and oncological targets.
• Fluorogenic Substrate Synthesis: Serves as a precursor for creating enzyme substrates where the 7-Amino-4-methylcoumarin (AMC) group acts as a fluorescent reporter upon cleavage.
• Protease Inhibitor Development: Employed in the design and synthesis of selective inhibitors for various proteolytic enzymes.
• Bioconjugation & Probe Chemistry: Useful for creating labeled peptides or cross-linked biomolecules for diagnostic and research applications.
• Academic & Institutional Research: A valuable reagent for studying peptide structure-activity relationships and enzyme kinetics in biochemical laboratories.

Basic Information

Product Name	Boc-Lys(Tfa)-Amc
CAS No.	97885-44-4
Molecular Formula	C₂₃H₃₀F₃N₃O₇
Molecular Weight	517.50 g/mol
Synonyms	Boc-Lys(Tfa)-AMC; Nα-(tert-Butoxycarbonyl)-Nε-(trifluoroacetyl)-L-lysine 7-amido-4-methylcoumarin; Boc-Lys(Tfa)-7-amido-4-methylcoumarin; tert-Butyl N-[(2S)-6-[(2,2,2-trifluoroacetyl)amino]-1-[(4-methyl-2-oxo-2H-chromen-7-yl)amino]-1-oxohexan-2-yl]carbamate; Boc-L-lysine(Tfa)-AMC; L-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-(trifluoroacetyl)-, 7-(4-methyl-2-oxo-2H-1-benzopyran-7-yl) ester; AMC derivative of Boc-Lys(Tfa)
EINECS	Contact for details

Quality Control

Our Boc-Lys(Tfa)-Amc is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20° to -24° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.