Description

Methotrexate-γ-Glycerophosphatidylethanolamine CAS NO 97850-20-9 is a specialized phospholipid conjugate of the established chemotherapeutic agent methotrexate. This compound is designed to enhance targeted drug delivery, potentially improving therapeutic efficacy while minimizing systemic side effects. It is primarily utilized by pharmaceutical researchers and developers in advanced drug delivery systems, particularly for oncology and autoimmune disease treatments.

Application

• Liposomal Drug Formulation: A key component in the development of liposome-encapsulated methotrexate for targeted cancer therapy.
• Advanced Oncology Research: Used in preclinical and clinical studies to investigate novel treatment strategies for solid tumors and hematologic malignancies.
• Autoimmune Disease Therapeutics: Research into more targeted delivery systems for conditions like rheumatoid arthritis and psoriasis.
• Bioconjugate Chemistry: Serves as a model compound for studying the linkage of active pharmaceutical ingredients to phospholipid carriers.
• Nanomedicine Development: Integral to the design of nanoparticle-based delivery platforms to improve pharmacokinetics and biodistribution.
• Academic & Institutional Research: Utilized in university and government labs for fundamental studies on membrane interactions and drug targeting.

Basic Information

Product Name	Methotrexate-γ-Glycerophosphatidylethanolamine
CAS No.	97850-20-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	MTX-γ-GPE; Methotrexate-γ-Glycerophosphoethanolamine; Methotrexate Phospholipid Conjugate; MTX-PE Conjugate; N-(Methotrexate-γ-yl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine; L-α-Phosphatidylethanolamine, N-(4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl)-; Phospholipid-Methotrexate Prodrug
EINECS	Contact for details

Quality Control

Our Methotrexate-γ-Glycerophosphatidylethanolamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.