Description

7-Hydroxy Aminopterin is a key derivative of the classic antifolate compound, aminopterin. This compound is of significant interest in biochemical and pharmaceutical research due to its structural modification, which can alter its biological activity and metabolic profile. It serves as a critical intermediate and reference standard for researchers in oncology, enzymology, and medicinal chemistry. The product is supplied with a high level of purity to ensure reliable and reproducible results in demanding laboratory and development environments.

Application

• Biochemical Research: Used as a reference standard and inhibitor in studies of dihydrofolate reductase (DHFR) enzyme kinetics and folate metabolism pathways.
• Pharmaceutical Development: Serves as a crucial intermediate in the synthesis and structure-activity relationship (SAR) studies of novel antifolate chemotherapeutic agents.
• Oncology Research: Employed in in vitro and cellular assays to investigate mechanisms of action, resistance, and synergy with other anticancer drugs.
• Analytical Standard: Provides a high-purity calibrant for analytical methods such as HPLC and LC-MS used in quality control and metabolic studies.
• Academic Studies: Utilized in university and institutional labs for fundamental research into cell proliferation, nucleotide biosynthesis, and targeted therapy.

Basic Information

Product Name	7-Hydroxy Aminopterin
CAS No.	97772-99-1
Molecular Formula	C19H18N8O5
Molecular Weight	438.40 g/mol
Synonyms	7-Hydroxy-4-aminofolic acid; 7-Hydroxy-4-aminopteroylglutamic acid; 4-Amino-7-hydroxy-pteroylglutamic acid; Aminopterin, 7-hydroxy-; 7-OH-Aminopterin; N-[4-[[(2,4-Diamino-7-hydroxypteridin-6-yl)methyl]amino]benzoyl]-L-glutamic acid
EINECS	Contact for details

Quality Control

Every batch of 7-Hydroxy Aminopterin is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure compliance with exacting standards for research chemicals. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.