Description

5-Aza-2'-Deoxy Cytidine 5'-Monophosphate is a chemically modified nucleoside monophosphate analog, serving as a critical biochemical tool and pharmaceutical intermediate. Its primary value lies in its role as an active metabolite of the DNA methyltransferase inhibitor decitabine, making it essential for epigenetic research and therapeutic development. This high-purity compound is specifically required by researchers in oncology, molecular biology, and by manufacturers developing novel chemotherapeutic agents and diagnostic assays.

Application

• Epigenetics Research: Used as a biochemical standard and substrate in studies of DNA methylation, gene silencing, and chromatin remodeling.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the production of nucleoside-based therapeutics, including DNA methyltransferase inhibitors.
• Biochemical Assay Development: Employed in the formulation of enzymatic assays to screen for and characterize inhibitors of DNA methyltransferases (DNMTs).
• Oncology Studies: Utilized in cell culture and in vitro models to investigate mechanisms of action and resistance in cancer therapy.
• Reference Standard: Acts as a high-purity analytical standard for quality control in pharmaceutical manufacturing and academic research.
• Nucleotide Chemistry: A building block for the synthesis of modified oligonucleotides for diagnostic and research applications.

Basic Information

Product Name	5-Aza-2'-Deoxy Cytidine 5'-Monophosphate
CAS No.	97763-83-2
Molecular Formula	C9H14N4O7P
Molecular Weight	321.21 g/mol
Synonyms	5-Aza-dCMP; 5-Aza-2'-deoxycytidine 5'-monophosphate; 5-Aza-2'-deoxycytidine monophosphate; Decitabine 5'-monophosphate; 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one 5'-monophosphate; 5-Aza-CdRMP; NSC 264580 monophosphate
EINECS	Contact for details

Quality Control

Our 5-Aza-2'-Deoxy Cytidine 5'-Monophosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.