Description

5-Chloro-5,8-Dideazaisoaminopterin is a high-purity, synthetic chemical intermediate of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in the field of oncology and targeted drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing next-generation antifolate analogs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antifolate compounds and enzyme inhibitors for targeted cancer therapies.
• Biochemical Research: Used as a reference standard or active compound in studies investigating dihydrofolate reductase (DHFR) inhibition and cellular metabolism pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Academic Research: Employed in university and institutional labs for fundamental research in chemical biology and drug mechanism of action.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and early-stage development projects for client companies.

Basic Information

Product Name	5-Chloro-5,8-Dideazaisoaminopterin
CAS No.	97541-74-7
Molecular Formula	C19H20ClN7O4
Molecular Weight	445.86 g/mol
Synonyms	5-Chloro-5,8-dideazaisoaminopterin; 5-Chloro-5,8-dideaza-isoaminopterin; 2-[[4-[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]amino]-4-chloro-pentanedioic acid; 5-Cl-DDIA; NSC 339531; 5-Chloro-5,8-dideazapteroic acid derivative; Antifolate intermediate
EINECS	Contact for details

Quality Control

Our 5-Chloro-5,8-Dideazaisoaminopterin is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.