Description

S-(2-Chloro-1,1,2-Trifluoroethyl)Glutathione is a specialized glutathione conjugate, a critical intermediate in the study of metabolic pathways and detoxification processes. This compound is essential for researchers and manufacturers investigating the biotransformation of halogenated hydrocarbons and the role of glutathione S-transferase enzymes. It serves as a key reference standard and building block for pharmaceutical development, toxicology studies, and advanced biochemical research. Professionals in medicinal chemistry and analytical laboratories rely on its high purity for accurate metabolic profiling and biomarker identification.

Application

• Biochemical Research: Used as a critical reference standard and substrate in enzymatic studies of glutathione S-transferase (GST) activity and specificity.
• Metabolic Pathway Analysis: Essential for investigating the detoxification and biotransformation pathways of chlorotrifluoroethane and related halogenated compounds.
• Pharmaceutical Intermediate: Serves as a key synthetic intermediate in the development of novel therapeutic agents and prodrugs targeting specific metabolic enzymes.
• Toxicology & Safety Assessment: Employed in studies to identify and quantify glutathione-derived metabolites for toxicological profiling and risk assessment of industrial chemicals.
• Analytical Standard: Provides a high-purity calibrant for LC-MS, HPLC, and other analytical methods used in biomarker discovery and metabolic phenotyping.
• Enzyme Mechanism Studies: Aids in elucidating the reaction mechanisms of conjugate formation and the fate of electrophilic xenobiotics in biological systems.

Basic Information

Product Name	S-(2-Chloro-1,1,2-Trifluoroethyl)Glutathione
CAS No.	97058-30-5
Molecular Formula	C12H18ClF3N3O6S
Molecular Weight	425.80 g/mol
Synonyms	L-Glutathione, S-(2-chloro-1,1,2-trifluoroethyl)-; S-(2-Chloro-1,1,2-trifluoroethyl)-L-glutathione; Glutathione S-(2-chloro-1,1,2-trifluoroethyl) conjugate; 2-Chloro-1,1,2-trifluoroethylglutathione; CTFEG; GST Conjugate of Chlorotrifluoroethane; NSC 339063; γ-Glu-Cys-Gly S-conjugate of 2-chloro-1,1,2-trifluoroethane
EINECS	Contact for details

Quality Control

Our S-(2-Chloro-1,1,2-Trifluoroethyl)Glutathione is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.