Description

Norfluoxetine n-β-D-Glucuronide is a crucial metabolite and reference standard used in advanced pharmaceutical research and development. This compound is essential for the accurate quantification and metabolic profiling of fluoxetine, a widely prescribed antidepressant. It serves as a vital analytical tool for researchers and quality control laboratories in the pharmaceutical and forensic toxicology sectors. The compound is supplied with a high level of purity to ensure reliable and reproducible results in sensitive analytical methods.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration of analytical instruments and validation of bioanalytical methods.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, bioavailability, and excretion profiles of fluoxetine and related compounds.
• Forensic and Clinical Toxicology: Used as a benchmark in assays to detect and quantify fluoxetine and its metabolites in biological samples for medical and legal purposes.
• Biomarker Research: Employed in studies aiming to identify and validate metabolic biomarkers related to SSRI (Selective Serotonin Reuptake Inhibitor) treatment.
• Quality Control (QC) in Manufacturing: Ensures the consistency and purity of active pharmaceutical ingredients (APIs) and finished drug products containing fluoxetine.
• Academic and Institutional Research: Supports fundamental research in neuropharmacology, medicinal chemistry, and analytical science.

Basic Information

Product Name	Norfluoxetine n-β-D-Glucuronide
CAS No.	96735-72-7
Molecular Formula	C25H30F3NO8
Molecular Weight	529.51 g/mol
Synonyms	Norfluoxetine Glucuronide; Norfluoxetine β-D-Glucuronide; (3S)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propane-1-amine Glucuronide; Fluoxetine Metabolite Glucuronide; Norfluoxetine N-Glucuronide; 96735-72-7; Norfluoxetine-O-glucuronide
EINECS	Contact for details

Quality Control

Every batch of Norfluoxetine n-β-D-Glucuronide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a reference standard, including purity verification by HPLC and structural confirmation by NMR and MS. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. Our quality commitment ensures compliance with the stringent requirements of pharmaceutical R&D and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.