Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-N,n-Dimethyl is a synthetic, cationic phospholipid derivative widely used in advanced formulation science. This compound is critical for creating stable, targeted delivery systems due to its ability to form non-bilayer structures and fuse with biological membranes. It is an essential raw material for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced cosmetics industries developing next-generation nanocarriers.

Application

• Lipid Nanoparticle (LNP) Formulation: A key cationic lipid component for the encapsulation and delivery of mRNA, siRNA, and other nucleic acids in therapeutic and vaccine applications.
• Liposome & Niosome Preparation: Used to formulate cationic liposomes for gene transfection, drug delivery, and diagnostic imaging agents.
• Cell Membrane Research: Serves as a fusogenic agent in studies of membrane fusion, lipid raft formation, and intracellular trafficking.
• Cosmetic Delivery Systems: Incorporated into nanocarriers for the enhanced skin penetration and stabilization of active cosmetic ingredients.
• Biomimetic Membrane Models: Employed in the construction of artificial membranes for biophysical studies and sensor development.
• Protein & Peptide Delivery: Facilitates the intracellular delivery of proteins, peptides, and enzymes for research and therapeutic purposes.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-N,n-Dimethyl
CAS No.	96687-22-8
Molecular Formula	C45H86NO8P
Molecular Weight	800.14 g/mol
Synonyms	DOPE-N,N-Dimethyl; N,N-Dimethyl-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Dimethyl-DOPE; 1,2-Dioleoyl-sn-glycero-3-phospho-N,N-dimethylethanolamine; Cationic DOPE; DODAP (common abbreviation); 18:1 DOPE-NMe2; N-Methylated DOPE
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-N,n-Dimethyl is manufactured under strict quality management systems. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency suitable for critical research and GMP-grade applications. A comprehensive Certificate of Analysis (COA) detailing purity, lipid profile, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
1,2-Dioleoyl Isomer Content	≥ 95.0%
Lyso-Impurity (HPLC)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.