Description

Trypanothione is a unique, low-molecular-weight thiol compound that serves as the central antioxidant and redox cofactor in trypanosomatid parasites, including those responsible for African sleeping sickness and Chagas disease. This makes it a critical and highly specific biochemical target for antiparasitic drug discovery and development. Researchers and pharmaceutical developers require high-purity trypanothione for use as a reference standard, enzyme substrate, and key reagent in biochemical assays and screening programs aimed at combating neglected tropical diseases.

Application

• Biochemical Research: Essential reference standard and substrate for studying trypanothione metabolism and redox biology in parasitic organisms.
• Drug Discovery: Key reagent in high-throughput screening (HTS) assays to identify and validate novel inhibitors of trypanothione reductase and synthetase.
• Enzymology Studies: Used to determine kinetic parameters and elucidate the catalytic mechanisms of parasite-specific enzymes.
• Diagnostic Development: Serves as a critical component in developing enzymatic and immunological diagnostic tests for parasitic infections.
• Parasitology: Fundamental tool for investigating parasite survival mechanisms, resistance pathways, and host-pathogen interactions.
• Antioxidant Research: Model compound for studying unique, non-glutathione-based antioxidant defense systems in lower eukaryotes.

Basic Information

Product Name	Trypanothione
CAS No.	96304-42-6
Molecular Formula	C27H48N10O12S2
Molecular Weight	768.86 g/mol
Synonyms	N1,N8-Bis(glutathionyl)spermidine; L-γ-Glutamyl-L-cysteinylglycyl spermidine disulfide; Trypanothione disulfide; T(SH)2 (reduced form); TS2 (oxidized form); NSC 326023; Glutathionylspermidine disulfide
EINECS	Contact for details

Quality Control

Our Trypanothione is produced under stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for research-grade biochemicals, ensuring reliable performance as a critical reagent in sensitive assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.