Description

1-(2-Deoxy-β-Ribofuranosyl)-5-Bromo-2-Pyrimidinone is a modified nucleoside derivative, a crucial building block in synthetic organic chemistry and pharmaceutical research. Its primary value lies in its role as a key intermediate for the synthesis of novel antiviral and anticancer nucleoside analogs, enabling targeted modifications to the sugar and base moieties. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who are developing next-generation therapeutic agents and diagnostic probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of experimental antiviral and anticancer nucleoside drugs.
• Biochemical Research: Used in oligonucleotide synthesis to incorporate modified bases for studying DNA/RNA structure, function, and protein interactions.
• Pro-drug Development: Serves as a building block for creating novel nucleoside pro-drugs designed for improved cellular uptake and metabolic activation.
• Antisense & siRNA Technology: Potential use in the development of modified antisense oligonucleotides or small interfering RNA (siRNA) for therapeutic applications.
• Diagnostic Probe Synthesis: Can be utilized to create labeled nucleosides for use in diagnostic assays and imaging techniques.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting fundamental research in medicinal chemistry and chemical biology.

Basic Information

Product Name	1-(2-Deoxy-β-Ribofuranosyl)-5-Bromo-2-Pyrimidinone
CAS No.	96245-87-3
Molecular Formula	C9H11BrN2O5
Molecular Weight	307.10 g/mol
Synonyms	5-Bromo-2'-deoxyuridine 2'-deoxy-5-bromouridine; 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil; 5-Bromo-2'-deoxyuridine (common name); 5-BrdU; BrdUrd; 5-Bromo-1-(2-deoxy-β-D-erythro-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione; 5-Bromodeoxyuridine
EINECS	Contact for details

Quality Control

Our 1-(2-Deoxy-β-Ribofuranosyl)-5-Bromo-2-Pyrimidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.