Description

26-Nor-25-Doxylcholestanol is a specialized spin-labeled sterol derivative, a crucial tool in biophysical and membrane research. Its value lies in its nitroxide radical (doxyl) group, which serves as a stable paramagnetic probe for Electron Paramagnetic Resonance (EPR) spectroscopy. This compound is essential for researchers and scientists in pharmaceutical R&D, biochemistry, and material science who require precise molecular reporters to study membrane fluidity, protein-lipid interactions, and molecular dynamics.

Application

• As a spin probe in Electron Paramagnetic Resonance (EPR) spectroscopy for studying membrane biophysics.
• Investigating lipid bilayer fluidity, phase transitions, and lateral organization in model and biological membranes.
• Researching sterol-protein interactions and their role in membrane structure and function.
• Use as a molecular reporter in structural biology studies to gain insights into conformational changes.
• Development and calibration of advanced analytical methods in biophysical chemistry.
• Fundamental research in material science for characterizing soft matter and ordered systems.

Basic Information

Product Name	26-Nor-25-Doxylcholestanol
CAS No.	96203-22-4
Molecular Formula	C₂₈H₄₇NO₂
Molecular Weight	429.68 g/mol
Synonyms	25-Doxyl-26-norcholestanol; 26-Norcholestan-25-ol, 3β-hydroxy-, 25-doxyl; 3β-Hydroxy-26-norcholestan-25-ol, 25-doxyl; Cholestane spin label; 25-DOXYL-26-NOR-CHOLESTANOL; Nitroxide-labeled cholestanol; EPR spin probe cholestanol derivative; Sterol nitroxide radical.
EINECS	Contact for details

Quality Control

Every batch of our 26-Nor-25-Doxylcholestanol is produced and analyzed under strict quality management protocols to ensure high purity and consistent performance for sensitive research applications. We guarantee identity, purity, and stability through comprehensive analytical techniques including HPLC, NMR, and EPR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under inert atmosphere when appropriate to maintain the stability of the nitroxide radical. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (EPR)	Active radical content ≥ 90%
Solubility	Soluble in common organic solvents (e.g., chloroform, ethanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.