Description

Fluoromethotrexate is a fluorinated analog of the established chemotherapeutic agent methotrexate, offering enhanced biochemical properties for advanced research and development. This compound is valued for its potential to act as a more potent or selective inhibitor of dihydrofolate reductase (DHFR), a key target in cancer and autoimmune disease pathways. It serves as a critical intermediate and reference standard for pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on novel antifolate therapies and targeted drug delivery systems.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of next-generation antifolate chemotherapeutic agents.
• Biochemical Studies: Used as a potent reference standard and inhibitor in enzymatic assays targeting dihydrofolate reductase (DHFR).
• Oncology Drug Discovery: Investigated for its potential to overcome methotrexate resistance in various cancer cell lines.
• Academic Research: Employed in universities and research institutes for studying folate metabolism and antifolate mechanisms of action.
• Fine Chemical Synthesis: Acts as a specialized building block for creating novel fluorinated pharmaceutical compounds.
• Reference Standard Manufacturing: Supplied to laboratories for quality control and analytical method development.

Basic Information

Product Name	Fluoromethotrexate
CAS No.	95755-20-7
Molecular Formula	C₂₀H₂₂FN₈O₅
Molecular Weight	464.44 g/mol
Synonyms	N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-4-fluoroglutamic acid; 4-Fluoro-L-glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-; 4-Fluoromethotrexate; F-MTX; Fluorinated Methotrexate; L-4-Fluoromethotrexate
EINECS	Contact for details

Quality Control

Our Fluoromethotrexate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.