Description

11,12-Leukotriene A4 is a specialized leukotriene derivative and a key intermediate in the biosynthesis of pro-inflammatory lipid mediators. This compound is of significant value for researchers investigating the intricate pathways of eicosanoid metabolism and inflammation. It is primarily utilized in advanced biochemical research and pharmaceutical development for studying leukotriene-related biological processes.

Application

• Biochemical Research: As a critical reference standard and intermediate for studying the lipoxygenase and leukotriene synthesis pathways.
• Pharmaceutical R&D: Used in the development and screening of novel anti-inflammatory drugs targeting leukotriene receptors or biosynthesis enzymes.
• Cell Signaling Studies: Employed to investigate the role of leukotrienes in immune response, allergic reactions, and cellular communication.
• Metabolite Analysis: Serves as a precursor or analytical standard in mass spectrometry and chromatography for metabolite profiling.
• Enzyme Activity Assays: Used as a substrate to study the activity and inhibition of key enzymes like LTA4 hydrolase or leukotriene C4 synthase.

Basic Information

Product Name	11,12-Leukotriene A4
CAS No.	95722-34-2
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	11,12-LTA4; Leukotriene A4 (11,12-isomer); (5S,6S)-5,6-Epoxy-7,9,11,14-eicosatetraenoic Acid; 5(6)-Epoxy-7,9,11,14-eicosatetraenoic Acid; LTA4 Methyl Ester (related derivative); 11,12-Epoxy-5,8,14-eicosatrienoic Acid
EINECS	Contact for details

Quality Control

Our 11,12-Leukotriene A4 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and stability. We adhere to relevant quality management standards to support our global clientele in pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Solvent Content (Residual)	≤ 1.0% (by NMR or GC)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.