Description

5,10-Dideaza-5,6,7,8-Tetrahydroaminopterin is a synthetic folate analog and a potent inhibitor of dihydrofolate reductase (DHFR). This compound is of significant interest in biochemical and pharmaceutical research due to its role in studying folate metabolism and its potential as a chemotherapeutic agent. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology research, metabolic pathway analysis, and the development of novel enzyme inhibitors.

Application

• Biochemical Research: As a key tool compound for studying the mechanism and kinetics of dihydrofolate reductase (DHFR) inhibition.
• Oncology Research: Investigation of its anti-proliferative effects and potential as a lead structure for novel anticancer therapeutics.
• Enzyme Inhibition Studies: Used to explore folate-dependent metabolic pathways in cellular and enzymatic assays.
• Pharmaceutical Development: Serves as a reference standard and intermediate in the R&D of antifolate drugs.
• Academic Research: Employed in universities and research labs for fundamental studies in biochemistry and medicinal chemistry.

Basic Information

Product Name	5,10-Dideaza-5,6,7,8-Tetrahydroaminopterin
CAS No.	95674-54-7
Molecular Formula	C19H23N7O5
Molecular Weight	429.43 g/mol
Synonyms	DDATHF; 5,10-Dideazatetrahydroaminopterin; 5,10-Dideaza-5,6,7,8-tetrahydrofolic acid; Lometrexol analog; NSC 127755; Antifolate DDATHF; 5,10-Dideaza-5,6,7,8-tetrahydropteroylglutamic acid
EINECS	Contact for details

Quality Control

Our 5,10-Dideaza-5,6,7,8-Tetrahydroaminopterin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.