Description

5,10-Dideazaaminopterin is a synthetic folate analog and potent inhibitor of dihydrofolate reductase (DHFR). This compound matters as a key biochemical tool for studying folate metabolism and cellular proliferation pathways in cancer research. It is primarily needed by pharmaceutical R&D laboratories and academic institutions for use as a reference standard and in the development of novel chemotherapeutic agents.

Application

• Biochemical Research: Used as a potent inhibitor of dihydrofolate reductase (DHFR) in enzymatic studies and metabolic pathway analysis.
• Oncology Research: Serves as a reference compound and tool molecule for investigating antifolate mechanisms and cellular proliferation in cancer cell lines.
• Pharmaceutical Development: Employed as an intermediate or reference standard in the research and development of novel chemotherapeutic agents.
• Academic Studies: Utilized in university and institutional laboratories for teaching and advanced research in medicinal chemistry and pharmacology.
• Analytical Standard: Acts as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	5,10-Dideazaaminopterin
CAS No.	95674-53-6
Molecular Formula	C19H21N7O4
Molecular Weight	411.42 g/mol
Synonyms	5,10-Dideaza-aminopterin; DDATHF; Lometrexol analog; 5,10-Dideazatetrahydrofolic acid; 5,10-Dideazafolic acid; NSC 127755; (2S)-2-[[4-[(1S)-1-[(2,4-Diaminopteridin-6-yl)methyl]butyl]benzoyl]amino]pentanedioic acid
EINECS	Contact for details

Quality Control

Our 5,10-Dideazaaminopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.