Description

Guanosine 5'-(Trihydrogen Diphosphate), Mono-α-D-Mannopyranosyl Ester, Dipotassium Salt is a high-purity biochemical nucleotide derivative, specifically a mannosylated GDP analog. This compound is critical for research and development in enzymology and carbohydrate metabolism studies, serving as a specialized substrate or inhibitor. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on glycosylation pathways, glycobiology, and the development of novel therapeutic agents.

Application

• Enzymatic Research: Used as a substrate or inhibitor in studies involving glycosyltransferases, particularly mannosyltransferases.
• Glycobiology Studies: Essential for investigating the biosynthesis of mannose-containing glycoconjugates, glycoproteins, and glycolipids.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the R&D of drugs targeting carbohydrate-mediated biological processes.
• Biochemical Assays: Employed in high-throughput screening (HTS) assays and in vitro diagnostic development for enzyme activity measurement.
• Academic Research: A vital tool for university and institutional labs studying nucleotide sugar metabolism and cell signaling pathways.
• Biocatalyst Development: Used in the development and optimization of enzymatic synthesis routes for complex carbohydrates.

Basic Information

Product Name	Guanosine 5'-(Trihydrogen Diphosphate), Mono-α-D-Mannopyranosyl Ester, Dipotassium Salt
CAS No.	95648-85-4
Molecular Formula	C16H23KN5O16P2 (or C16H25K2N5O16P2)
Molecular Weight	~ 659.42 g/mol (Free acid). Contact for exact salt form weight.
Synonyms	GDP-Mannose, Dipotassium Salt; Guanosine Diphosphate Mannose (K2 salt); GDP-α-D-Mannose; GDP-Man; 5'-GDP-α-D-Mannopyranosyl Ester Dipotassium Salt; Guanosine 5'-(trihydrogen diphosphate) P'-α-D-mannopyranosyl ester, dipotassium salt; Mannose-1-phosphate guanylyltransferase substrate.
EINECS	Contact for details.

Quality Control

Our Guanosine 5'-(Trihydrogen Diphosphate), Mono-α-D-Mannopyranosyl Ester, Dipotassium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for life science research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 5.0 %
pH (1% Solution)	6.0 - 8.0
Specific Rotation	Contact for details
Biological Activity	Tested as substrate for specific glycosyltransferases (data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.