Description

Suc-Ala-Pro-Pna CAS NO 95632-46-5 is a synthetic peptide substrate designed for biochemical research and diagnostic applications. This compound is a critical reagent for the study and detection of specific protease enzymes, particularly dipeptidyl peptidase IV (DPP-IV) and related serine proteases. It is primarily utilized by pharmaceutical researchers, diagnostic kit manufacturers, and academic laboratories engaged in enzyme kinetics, inhibitor screening, and assay development.

Application

• Enzyme Activity Assays: As a chromogenic substrate for the continuous spectrophotometric measurement of DPP-IV (CD26) activity.
• Drug Discovery Screening: High-throughput screening (HTS) of potential DPP-IV inhibitors for metabolic disease (e.g., type 2 diabetes) and cancer research.
• Diagnostic Reagent: A key component in clinical diagnostic kits for measuring DPP-IV levels in serum or plasma samples.
• Biochemical Research: Used in fundamental research to characterize protease specificity, kinetics (Km, Vmax), and catalytic mechanisms.
• Quality Control: Employed in the QC testing of biopharmaceuticals where DPP-IV activity must be monitored or controlled.

Basic Information

Product Name	Suc-Ala-Pro-Pna
CAS No.	95632-46-5
Molecular Formula	C20H26N4O7
Molecular Weight	434.45 g/mol
Synonyms	Succinyl-Ala-Pro-p-nitroanilide; Suc-Ala-Pro-pNA; Suc-AP-pNA; DPP-IV Substrate; Dipeptidyl Peptidase IV Substrate; N-Succinyl-Ala-Pro-p-nitroaniline; N-Succinyl-Alanyl-Prolyl-4-nitroanilide; Ala-Pro-pNA (Suc-)
EINECS	Contact for details

Quality Control

Our Suc-Ala-Pro-Pna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and functional validation in enzymatic assays. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure reproducible performance in your critical research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Optical Rotation	Contact for details
Functional Activity	≥ 95% of reference standard in DPP-IV assay
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.