Description

Hyaluronic Acid, High-Sulfated is a chemically modified derivative of hyaluronic acid, characterized by a high degree of sulfation on its polysaccharide backbone. This modification significantly enhances its biological activity, particularly its binding affinity for growth factors and its anti-angiogenic properties, making it a critical advanced material for high-value applications. It is primarily sought by research institutions and manufacturers in the pharmaceutical, biomedical, and advanced cosmetic sectors for developing next-generation therapeutics and sophisticated delivery systems.

Application

• Biomedical Research & Drug Delivery: As a key component in creating scaffolds for tissue engineering and as a carrier for controlled-release drug delivery systems, leveraging its enhanced protein-binding capabilities.
• Pharmaceutical Development: For formulating advanced ophthalmic solutions, wound healing gels, and anti-arthritic injectables where its potent biological activity is utilized.
• Advanced Cosmeceuticals: In high-performance anti-aging serums and creams, where its superior moisture retention and skin-repair properties compared to standard hyaluronic acid are valued.
• Diagnostic Reagents: Used in the development of biochemical assays and diagnostic kits that require specific glycosaminoglycan interactions.
• Cell Culture & Regenerative Medicine: As a specialized substrate or medium additive to influence cell behavior, differentiation, and tissue growth in vitro.

Basic Information

Product Name	Hyaluronic Acid, High-Sulfated
CAS No.	95507-66-7
Molecular Formula	(C14H21NO11S)n
Molecular Weight	Variable (Polymer)
Synonyms	Highly Sulfated Hyaluronic Acid; HS-HA; Sulfated Hyaluronan; Hyaluronan Sulfate; Glycosaminoglycan, Sulfated; Heparin-mimetic Polymer; 4-β-D-Glucopyranuronosyl-(1→3)-N-acetyl-β-D-glucosamine, Sulfated; Sodium Hyaluronate Sulfate
EINECS	Contact for details

Quality Control

Our Hyaluronic Acid, High-Sulfated is produced under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including assessment of degree of sulfation, molecular weight distribution, purity, and biological activity to ensure consistency and performance. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ISO 9001 standards for research and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive). Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, consider storage under desiccant or inert atmosphere. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or fibrous solid
Identification (IR)	Conforms to structure
Degree of Sulfation (DS)	> 2.0 (Customizable)
Assay (as dry basis)	≥ 95%
Protein Content	≤ 0.1%
Nucleic Acid Content	≤ 0.05%
Loss on Drying	≤ 8.0%
Heavy Metals (as Pb)	≤ 10 ppm
Bacterial Endotoxins	< 0.5 EU/mg (if applicable)
Sterility	Can be supplied sterile (upon request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.